Detailed Dissolution Calculator (Mean, RSD, f1 & f2)
Detailed Dissolution Calculator
(Mean, RSD, f1 & f2)
Enter data for each row (time point, medium, 12 individual unit results). The system calculates the mean & RSD.
Make sure the Reference and Test tables have matching rows (same order of time points) if you want f1 & f2.
Then click "Calculate" at the bottom.
Reference Product
Time (min)
Medium
R1
R2
R3
R4
R5
R6
R7
R8
R9
R10
R11
R12
Mean (%)
RSD (%)
Test Product
Time (min)
Medium
T1
T2
T3
T4
T5
T6
T7
T8
T9
T10
T11
T12
Mean (%)
RSD (%)
Common Similarity Criteria
ICH/WHO: Typically, f1 ≤ 15 and f2 ≥ 50 indicate dissolution similarity.
USP: Generally, f2 ≥ 50 is acceptable to demonstrate similarity.